The current study aimed to investigate post-graduation depression Career and future concern among sample of graduate students from Sultan Qaboos University and find out the differences in the levels of post-graduation depression and Career future concern according to study variables (gender, income level, C-GPA, and the year of graduation). It also aimed to predicting the level of post-graduation depression through dimensions of Career future concern among graduates, The study used descriptive correlative approach and for the purpose of achieving the objectives of the study, the Arabic version of Patient Health Scale-9 was used to measure depressive symptoms, as well as Career future anxiety scale. The sample included 534 Job seeker graduates of Sultan Qaboos University with a bachelor's degree in Sultanate of Oman. selected between the years 2016 and 2021 using the available sampling method. The data analyzed using SPSS Statistics, included means, SDs, independent samples t-test and one-way ANOVA and multiple linear regression analysis. The results showed Moderate level of post-graduation depression and Moderate level of Career future concern among the study sample, the results also indicated no statistically significant differences in the levels of post-graduation depression according gender at the level of significance (α=0.05) while it was found that there were statistically significant differences between males and females in the levels of career future anxiety in favor of males. It also showed Statistical significance of the levels of post-graduation depression and career future concern due to the level of the graduation year in favor of the years 2018 and less. There were differences due to the level of the CGPA in favor of the CGPA to passable level (2.00 - 2.29), and there are statistically significant differences in both post-graduation depression and future career concern according to the income variable. The results also indicated that there is a statistically significant correlation between the two variables of the study, where post-graduation depression can be predicted through the dimensions of career future concern (the cognitive dimension, the physiological dimension and the behavioral dimension) among the sample of Sultan Qaboos University graduates, and that the three dimensions are responsible for 39% of post-graduate depression, and 61% are represented by other factors that have the ability to predict post-graduate depression. The study came out with a set of recommendations and suggestions in the field of psychological counseling and graduates looking for work in general.