This study aims to identifying the relationship between mental health and meaning in life of the students in the eleventh grade in Al-Buraimi Governorate and its relationship with some demographic variables (gender, specialization and age). The study sample is consisted of (662) students of the students eleventh grade in Al- Buraimi Governorate, Sultanate of Oman. They have been chosen through available way. The first is Arabic scale for the mental health, prepared by Abdul Khaliq (2010) and the second is the Brief Personal Meaning Profile prepared by (Macdonald, et al, 2012); 1 tramslated and prepared by the researcher used in. This study showed that: For the eleventh grade students in Al- Buraimi Governorate, Sultanate of Oman: the level of mental health and meaning in life is moderate. There are statistically significant differences attributed to the social type variable in mental health in favor of male students, While there are no statistically significant differences attributed to the specialization and age variable in mental health. Also, There are no statistically significant differences attributed to the gender variable in the meaning in life in the five dimensions (achievement, relationship, self-transcendence, self acceptance and fair treatment), while there are statistically significant differences in religion and intimacy and affection dimensions in favor of male students. There are no statistically significant differences attributed to the specialization variable in the meaning in life in the six dimensions (relationship, religion, self transcendence, self-acceptance, intimacy and affection, and fair treatment), while there are statistically significant differences in achievement dimension in favor of Literary Specialization. There are no statistically significant differences attributed to the age variable in the meaning in life. There is a positive significant relationship between the level of mental health measurement and the meaning in life measurement. The resulte revealed also that significant contribution of variance of meaning in life in meantal health.